A well-structured Cloud architecture can help organizations get the best business value from their investments and make their applications future-ready. Some of the best practices to follow are,

1. Map out the exact need of Cloud capabilities and continuously test the architecture during development for unexpected glitches. 
2. Secure your Cloud architecture from security threats and encourage data encryption and patch management for hybrid and multi-cloud infrastructure. 
3. Ensure maximum disaster recovery with automation to avoid system downtime and disruptions. 
4. Leverage best resources and monitor user expectations and technology demands to make the most of your infrastructure.